MFN1 Polyclonal Antibody（试剂）_100 μg

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100 μg

RH305115

PA5-38042

1kg单位：瓶

7-10品 牌：Invitrogen

0

产品详细信息

A recommended positive control is A431 cell lysate.

MFN1 antibody is not expected to cross-react with MFN2.

靶标信息

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.

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