三（2-羧乙基）膦 盐酸盐_2G

General description

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP.HCl) is a non-volatile solid. It is a strong reducing agent.1^[5] It can be synthesized by the acid hydrolysis of tris(2-cyanoethyl)phosphine in refluxing aqueous HCl.1^[5] It has various biological applications such as in vitro and in vivo reduction of disulfide bonds in various peptides and proteins. TCEP is a useful chelating agent for various heavy metal ions as Zn(II), Cd(II), Pb(II), and Ni(II).^[4]

Application

Tris(2-carboxyethyl)phosphine hydrochloride (TCEP. HCl) can be used:
• As a reducing agent for the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides. It can also be used in azide-alkyne cycloaddition reaction in the presence of a copper catalyst.^[6]
• To reduce disulfide bonds in various proteins.^[6]
• As a reagent for the selective reduction of disulfides in water.^[5]
• To remove ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture when it is basified.^[1][2]
• As a reducing agent for the reduction of various alkyl disulfides such as trans-4,5-dihydroxy-1,2-dithiane.^[5]

水溶性试剂，用于二硫化物的选择性还原。在质谱应用中比 DTT 更稳定。

包装

2, 10, 50 g in glass bottle

Caution

储存条件：干燥储存。