POROS™ CaptureSelect™ AAVX Affinity Resin（试剂）_10 mL
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10 mL
RH307472
A36739
1kg单位：瓶
7-10品 牌：Thermo Scientific
0
描述POROS CaptureSelect AAVX Affinity Resin is engineered to address the high selectivity and capacity requirements for large-scale downstream purification of a broad range of naturally occurring and synthetic adeno-associated virus (AAV) serotypes used for gene therapy applications. POROS CaptureSelect AAVX resin has demonstrated binding reactivity towards a set of AAV serotypes that includes AAV1 to AAV8, and AAVrh10 as well as synthetic serotypes.Features of POROS CaptureSelect AAVX resin include: • One-step AAV purification from crude material with high purity and yield • High specificity and capacity, maximizing yield by significantly reducing process steps • Superior capacity maintained at high flow rates • Excellent scalability and easier handling and packing due to rigid polymeric bead • Non-animal derived POROS CaptureSelect AAVX Affinity Resin enables a robust, fast, and platformable purification process for wide-ranging AAV serotypes with excellent purity and yield obtained in one step. This resin comes with complete technical and regulatory support. View other viral vector resins and supporting products › Main characteristics Matrix: cross-linked poly(styrene-divinylbenzene) POROS beads Average particle size: 50 µm Ligand: CaptureSelect AAVX affinity ligand Binding capacity: >1x1013 genome copies/mL of resin Elution conditions: acidic elution with 0.1 M glycine, pH 3.0 Mechanical resistance: 100 bar (1,450 psi; 10 MPa) Formulation buffer: 18% (v/v) ethanol CaptureSelect affinity ligands are created using a proprietary technology based on camelid-derived single-domain antibody fragments. The ligand is a 13-kDa fragment that comprises the three complementarity determining regions (CDRs) that form the antigen-binding domain, efficiently produced by the yeast Saccharomyces cerevisiae in a production process free of animal components. |
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