ZO-1 Polyclonal Antibody（抗体试剂）_100 μg

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100 μg

RH460571

40-2200

1kg单位：支

7-10品 牌：Invitrogen

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产品规格

种属反应

Dog, Human, Mouse, Rat

已发表种属

Chicken, Dog, Human, Mouse, Non-human primate, Pig, Rat, Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide in the middle region of the ZO-1 protein.

偶联物

Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

RRID

AB_2533456

产品详细信息

40-2200 was used successfully in the immunofluorescence analysis of Zo-1 in MDCK cells.

靶标信息

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

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