Dectin-1 Polyclonal Antibody（抗体）_100uL/盒

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100uL/盒

RH477636

PA5-97284

1kg单位：盒

28-42品 牌：Invitrogen

0

产品详细信息

Immunogen sequence: SWDGSKRQCW QLGSNLLKID SSNELGFIVK QVSSQPDNSF WIGLSRPQTE VPWLWEDGST FSSNLFQIRT TATQENPSPN CVWIHVSVIY DQLCSVPSYS I

Positive Samples: H-460, SGC-7901, HL-60, Mouse spleen, Mouse thymus, Mouse liver, Mouse lung, Rat spleen; Cellular Location: Cell membrane, Cytoplasm, Single-pass type II membrane protein

靶标信息

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

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