DNase I Polyclonal Antibody（试剂）_100 μL

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100 μL

RH484334

PA5-22017

1kg单位：盒

5-7品 牌：Invitrogen

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产品详细信息

Recommended positive controls: Molt-4.

Predicted reactivity: Dog (81%), Rabbit (81%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Internucleosomal DNA fragmentation following the activation of endonucleases is the common end point of apoptosis. DNase I, a Ca2+/Mg2+-dependent endonuclease ubiquitously expressed in mammalian tissues, has been implicated to mediate internucleosomal DNA degradation in human cells undergoing apoptosis. DNase I is highly polymorphic, and at least six alleles of DNase I are known. DNase II, the ubiquitously expressed acidic deoxyribonuclease, acts downstream of caspase activation and may also induce DNA digestion during apoptosis. DNase I cleaves DNA to 5'-phosphodinucleotide and 5'-phospho- oligonucleotide end-products, whereas DNase II cleaves DNA to 3'-phosphomononucleotide and 3'-phosphooligonucleotide end-products. The mechanism by which DNase II cuts DNA is similar to DNase I, which produces nicks rather than double-strand cuts. DNase II is usually present in cytoplasm of epithelial cells, but it appears concentrated in the nuclei of lens fibers. In contrast, DNase I is always concentrated in nuclei of epithelial and fiber cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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