Phospho-SMAD2/SMAD3 抗体_100 μL
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100 μL
RH488530
PA5-110155
1kg单位：瓶
5-7品 牌：Invitrogen
0
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Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) Polyclonal Antibody
产品详细信息
In Western blot applications, this antibody detects a band at ~34kDa. A suggested positive control is human heart tissue lysate. 靶标信息This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. 仅用于科研。不用于诊断过程。未经明确授权不得转售。 |
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