FPR1 Polyclonal Antibody（抗体）_100 μg

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100 μg

RH489661

PA1-41398

1kg单位：瓶

7-14品 牌：Invitrogen

0

产品详细信息

Suggested positive control: human liver protein, liver lysate.

Immunogen sequence: CTFNFSPWTN DPKER

靶标信息

FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeleton, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates.

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