Phospho-STING (Ser366) Polyclonal Antibody（抗体）_100 μL

市场价：￥4969会员价请登录

100 μL

RH490612

PA5-105674

1kg单位：支

5-7品 牌：Invitrogen

0

产品详细信息

Antibody detects endogenous levels of TMEM173/STING only when phosphorylated at Ser366.

靶标信息

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

x

江浙沪地区邮费 10 元，满 200 包邮  其它地区(不含港澳台)邮费 20 元，满 1000 包邮